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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Paclitaxel
supplement:
Docosahexaenoic Acid
Research Papers that Mention the Interaction
“When the increase in taxanes efficacy was measured by dividing the IC50 values (50% … were exposed to taxanes alone by those after DHA pre-exposure, we found that DHA enhanced the cytotoxic activity of taxanes against MDA-MB-231 … manner (up to 13- and 5-fold increase in Taxol …).”
Exogenous supplementation with omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA; 22:6n-3) synergistically enhances taxane cytotoxicity and downregulates Her-2/neu (c-erbB-2) oncogene expression in human breast cancer cells.
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