supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Paclitaxel
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“The effects of adding paclitaxel were … subset analysis, the hazard ratio of CA … paclitaxel versus CA alone was 0.72 (95% confidence interval, 0.59 to 0.86) for those with estrogen … to 1.07) for patients with estrogen receptor-positive tumors, almost all of whom received adjuvant tamoxifen.”
“The hazard reductions from adding paclitaxel to CA were 17% for recurrence (adjusted Wald chi(2) P =.0023; unadjusted Wilcoxon P =.0011) and 18% for death (adjusted P =.0064; unadjusted P =.0098).”
Improved outcomes from adding sequential Paclitaxel but not from escalating Doxorubicin dose in an adjuvant chemotherapy regimen for patients with node-positive primary breast cancer.“ Calcium also acts as a direct biological barrier for paclitaxel uptake during DCB inflation, influencing the homogenous distribution of the drug such that an adequate concentration cannot be predicted.”
“ Taxol , another antineoplastic drug, specifically inhibited calcium triggered exocytosis.”
Application of a Membrane Fusion Assay for Rapid Drug Screening“Pretreatment of cells with Taxol and cold storage in the UW solution with 1.5 mM Ca suppressed both bleb formation and LDH release in 48-hr coldstored cells.”
“ Taxol significantly inhibited contraction induced by phenylephrine, angiotensin II, phorbol 12,13-dibutyrate and increasing concentrations of calcium.”
“ Taxol stabilizes microtubules against the depolymerizing effects of cold temperature, drugs and Ca++.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback