Possible Interaction: Paclitaxel and Apigenin

“Here we report that the use of apigenin can suppress the HIF-1α expression in hypoxic tumors through the simultaneous inhibition of the AKT/p-AKT pathway and HSP90, which is beneficial for enhancing the anticancer activity of the co-administered paclitaxel.”

“The potential synergistic effect of apigenin and paclitaxel was further validated on HepG2 cell line and tumor-bearing mouse models.”

“Here, we used the graphene oxide coated nanotised apigenin (GO-NA) to enhance the efficacy of paclitaxel.”

“Conclusions/Significance Taken … study demonstrated that apigenin can sensitize … cells to paclitaxel induced apoptosis through suppressing SOD activity, which then led to accumulation of ROS and cleavage of caspase-2, suggesting … the combined use of apigenin and paclitaxel was an effective way to decrease the dose of paclitaxel taken.”

“Methodology/Principal Findings Our results from cell viability assay, western-blots and TdT-mediated dUTP-biotin nick end labeling (TUNEL) assay demonstrated the synergistic pro-apoptotic effects of a low dose of apigenin and paclitaxel in human cancer cell lines.”

“The AUCs and Cmax of paclitaxel were increased with apigenin and rutin in the dose-dependent manner.”

“The absorption of paclitaxel was increased in the presence of apigenin , rutin, and verapamil, a typical P-glycoprotein and Cyp3A4 inhibitor.”

“The areas under the plasma concentration–time curve (AUC) and the plasma peak concentrations (Cmax) of paclitaxel with apigenin and rutin were significantly higher (p < 0.01) than that of the control.”