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Last Updated: 3 years ago

Possible Interaction: Oxytocin and Verapamil

supplement:

Oxytocin

Research Papers that Mention the Interaction

However, SBL and VER significantly increased (p < 0.01) the EC50, of OT , ACh and EGM and significantly inhibited (p < 0.01) the frequency and amplitude of spontaneous uterine contractions.
Acta poloniae pharmaceutica  •  2011  |  View Paper
However, significant differences (p <0.01) were observed in the EC50 and Emax of the extract and oxytocin in the presence of verapamil.
Pharmaceutical biology  •  2010  |  View Paper
Treatment with verapamil , an antagonist specific for these channels, significantly diminished MLC phosphorylation observed in response to oxytocin administration without affecting the release of Ca2+ from intracellular Ca2+ stores.
Journal of molecular recognition : JMR  •  2001  |  View Paper
These results suggest that verapamil has a central site of action on stimulated oxytocin release (including an action within the SON) and that both pre and post-synaptic L-type Ca(2+) channels are required for the full expression of morphine withdrawal in SON oxytocin neurones.
verapamil reduced suckling-induced release of oxytocin within the SON.
Neuropharmacology  •  2000  |  View Paper
Oxytocin produced an acute decrease in this threshold dose on phentolamine or methysergide, but was inhibited by papaverine, dibutyryl cAMP, salbutamol and verapamil.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica  •  1981  |  View Paper