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Last Updated: 5 years ago

Possible Interaction: Oxytocin and Verapamil

supplement:

Oxytocin

Research Papers that Mention the Interaction

“However, SBL and VER significantly increased (p < 0.01) the EC50, of OT , ACh and EGM and significantly inhibited (p < 0.01) the frequency and amplitude of spontaneous uterine contractions.”
Acta poloniae pharmaceutica  •  2011  |  View Paper
“However, significant differences (p <0.01) were observed in the EC50 and Emax of the extract and oxytocin in the presence of verapamil.”
Pharmaceutical biology  •  2010  |  View Paper
“Treatment with verapamil , an antagonist specific for these channels, significantly diminished MLC phosphorylation observed in response to oxytocin administration without affecting the release of Ca2+ from intracellular Ca2+ stores.”
Journal of molecular recognition : JMR  •  2001  |  View Paper
“These results suggest that verapamil has a central site of action on stimulated oxytocin release (including an action within the SON) and that both pre and post-synaptic L-type Ca(2+) channels are required for the full expression of morphine withdrawal in SON oxytocin neurones.”
“ verapamil reduced suckling-induced release of oxytocin within the SON.”
Neuropharmacology  •  2000  |  View Paper
“ Oxytocin produced an acute decrease in this threshold dose on phentolamine or methysergide, but was inhibited by papaverine, dibutyryl cAMP, salbutamol and verapamil.”
Nihon yakurigaku zasshi. Folia pharmacologica Japonica  •  1981  |  View Paper