Possible Interaction: Oxytocin and Vardenafil

“Conclusions In this study, we showed that the PDE-5 inhibitor, vardenafil directly enhances oxytocin expression and also activates oxytocin neurons in the PVN, which indicates that vardenafil may exert positive effects on affiliation behavior and social interaction.”

“Results Oxytocin expression in the PVN was increased by 1 day administration of 2 mg/kg vardenafil , and this effect of vardenafil appeared in a duration-dependent manner.”

“c-Fos in the oxytocin neurons of the PVN was increased by 1 day administration of 2 mg/kg vardenafil , and this effect of vardenafil also appeared in a duration-dependent manner.”