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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
Research Papers that Mention the Interaction
“ RA treatment produced a significant increase (2- to 3-fold) both in the OT concentration and in the OT mRNA levels.”
Oxytocin in cardiac ontogeny.“Here, we show that in vivo administration of RA similarly induces a significant increase in uterine OT gene expression.”
“Using short-term uterine organ explant cultures derived from 18-day pregnant rats, we found that E (50 nM) and RA (0.4 nM) increased OT mRNA levels 5.2- and 3-fold, respectively, suggesting a direct action of these agents on uterine OT gene expression.”
“Our studies constitute the first report of a RARE in a neuropeptide gene and define a mechanism by which OT gene expression can be modulated by retinoic acid.”
“ RA elicited a marked stimulation of the transcriptional activity of the OT promoter in cells cotransfected with either the human RA receptor alpha, beta, or gamma.”
“Here it is shown that the rat OT promoter is stimulated (at least 20-fold) by retinoic acid through two distinct regions in the 5'-flanking region.”
A composite hormone response element mediates the transactivation of the rat oxytocin gene by different classes of nuclear hormone receptors.
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