Possible Interaction: Oxytocin and Rabbit Allergenic Extract

“The post-partum uterus of the rabbit is extremely sensitive to oxytocin , the threshold dose on the first post-partum day, being about 0.03 mu.”

“Intravenous injection of 0.1 mU oxytocin into a rabbit has a definite effect on the first day after delivery, but this sensitivity decreases during the following 4-5 days (Fuchs Se Fuchs 1960).”

“The disappearance rate of intact, parent oxytocin when an oxytocin solution was placed in direct contact with the serosal and mucosal sides of freshly excised rabbit buccal mucosa was 0.74 +/- 0.34 microgram/cm2/hr and 3.38 +/- 1.07 micrograms/cm2/hr, respectively.”

“Intravenous injection of synthetic oxytocin (Syntocinon) causes a fall of blood pressure in rabbit.”

“There was a straight line relationship between peak oxytocin concentrations in the plasma and the speed of delivery, implying that oxytocin facilitates as well as maintains labour in the rabbit.”

“The Km values for MgATP are 2.15 mM. Oxytocin added to the homogenization medium containing rabbit and cattle myometrium cells, i.e. during the formation of closed sarcolemmal fragments, resulted in inhibition of Mg2+, ATP-dependent accumulation of 45Ca2+ by plasma membranes.”

“Intravenously administered oxytocin caused a dose-related fall in blood pressure of the rabbit.”

“There appears, therefore, to be a powerful overriding central inhibitory mechanism in the rabbit which can prevent release of oxytocin , even when the appropriate stimulus for release is applied.”