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Last Updated: 3 years ago

Possible Interaction: Oxytocin and Phenytoin

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supplement:

Oxytocin

drug:

Phenytoin

Research Papers that Mention the Interaction

“The sustained contractions induced by K+, acetylcholine (ACh) and oxytocin (Ot) were inhibited in a concentration-dependent fashion by diphenylhydantoin (DPH) and nifedipine (NIF) in the following order of sensitivity: K+ greater than ACh greater than Ot.”

Effect of diphenylhydantoin on drug and calcium induced contractions of isolated rat uterus: a comparative study with nifedipine.

General pharmacology • 1987 | View Paper

“The effects of diphenylhydantoin and bretylium differ with respect to their dependence on external pH. The diphenylhydantoin or the bretylium stimulatory effects are additive to the effects of oxytocin.”

Comparison between bretylium and diphenylhydantoin interaction with mucosal sodium-channels.

Biochimica et biophysica acta • 1984 | View Paper

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