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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Oxytocin
drug:
Phentolamine
Research Papers that Mention the Interaction
“Furthermore, pretreatment with phentolamine significantly diminished systemic OT release in response to icv Ang II.”
Angiotensin II-induced release of oxytocin: interaction with norepinephrine and role in lactation“In addition, a co‐infusion of oxytocin with phentolamine abolishes recognition responses (experiment 3).”
“Furthermore, the increases in OT concentration in dialysates and plasma were prevented by simultaneous administration of chlorpheniramine (an H1 receptor antagonist) or ranitidine (an H2 receptor antagonist) as well as by the adrenergic antagonist phentolamine.”
“Stimulation of peripheral alpha-adrenergic receptors with phenylephrine did not affect either basal or suckling-induced OT release, but blockade of alpha-adrenergic receptors with phentolamine also completely prevented the release of OT by suckling.”
“ Oxytocin produced an acute decrease in this threshold dose on phentolamine or methysergide, but was inhibited by papaverine, dibutyryl cAMP, salbutamol and verapamil.”
“In intact rats, alpha adrenergic receptor blocking agents, phenoxybenzamine (PBZ) and phentolamine potentiated the pressor response to oxytocin and vasopressin (VP).”
“In the presence of PBZ or phentolamine blockade, the dose-response curves of oxytocin and VP were shifted to the left, resulting in an apparent doubling of the pressor potency of the neurohypophysial peptides.”
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