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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Oxytocin
drug:
Phenoxybenzamine
Research Papers that Mention the Interaction
“In normoxic tissues, phenoxybenzamine (20 microM) decreased the maximum contractile response (EMAX) to oxytocin (155+/-17 vs. 66+/-19 g s/cm2) and oxytocin binding sites (BMAX: 253+/-35 vs. 114.9+/-21.3 fmol/mg protein).”
Functional determination of oxytocin affinity in near-term pregnant rat myometrium: effect of chronic hypoxia.“The release of oxytocin evoked by dopamine and noradrenaline was prevented by cis-flupenthixol and phenoxygenzamine respectively.”
“In intact rats, alpha adrenergic receptor blocking agents, phenoxybenzamine (PBZ) and phentolamine potentiated the pressor response to oxytocin and vasopressin (VP).”
“In the presence of PBZ or phentolamine blockade, the dose-response curves of oxytocin and VP were shifted to the left, resulting in an apparent doubling of the pressor potency of the neurohypophysial peptides.”
“5 Phenoxybenzamine , in a dose which almost blocked the actions of the catecholamines, increased the responses of the vascular and capsular smooth muscle to oxytocin , vasopressin and angiotensin.”
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