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“The chiral conformation that palmitoleic acid takes when it is bound to ToxT , the master regulator of virulence genes in the bacterial pathogen Vibrio cholerae, was used as inspiration to design a novel class of fatty acid mimetics.”
ACS medicinal chemistry letters • 2021 | View Paper
“The finding that cis-palmitoleic acid reduces TCP and CT expression in V. cholerae and prevents ToxT from binding to DNA in vitro provides a direct link between the host environment of V. cholerae and regulation of virulence gene expression.”