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Last Updated: 3 years ago
supplement:
Oxytocin
Research Papers that Mention the Interaction
“In the presence of L-NAME , plasma AVP and OT levels rose 3-fold in response to hypoglycemia and were significantly higher than those in the control test.”
Gamma-aminobutyric acid mediation of the inhibitory effect of nitric oxide on the arginine vasopressin and oxytocin responses to insulin-induced hypoglycemia“Since oxytocin's effects during the early phase were also antagonized by Nω-nitro-l-arginine methyl ester , ODQ, or glibenclamide (inhibitors of nitric oxide synthase [NOS], soluble guanylyl cyclase [GC], and K+ATP channels, respectively), the role of two differential pathways elicited by oxytocin is supported.”
In Vivo Dissection of Two Intracellular Pathways Involved in the Spinal Oxytocin-Induced Antinociception in the Rat.“In addition, administration of l-NAME prior to OT partially reversed the protective effect of OT ensuring that one of the protective effects of OT was through the NO production.”
“Atosiban, 5HD, L-NAME and indomethacin abolished the postconditioning effect of OT.”
“The ANP receptor antagonist (anantin) and NO synthases inhibitor l-NAME ) inhibited cGMP production in CMs exposed to OT.”
“In L-NAME + MgSO4 given group at each oxytocin concentrations, the frequencies of the contractions in ten-min period were lower but not statistically different than the L-NAME group.”
“Pretreatment of L-NAME (10 mmol/L, 100 nl), the nitric oxide synthase (NOS) inhibitor, or methyl blue (10 mmol/L, 100 nl), the guanylyl cyclase inhibitor, inhibited the excitatory effect of OT on gallbladder motility.”
“The effects of OT were also blocked by hexamethonium, a ganglionic blocking agent, by atropine, a muscarinic receptor antagonist, and by N(omega)-nitro-L-arginine methyl ester , an inhibitor of nitric oxide synthesis.”
“Treatment of morphine‐dependent rats with Nω‐nitro‐l‐arginine methyl ester also enhanced oxytocin secretion during naloxone‐precipitated withdrawal.”
“Co-perfusion with 10−… NO synthase inhibitor L-NAME) … oxytocin effects on both beating rate (−1.85±1.27% versus −14.7±4.9% in oxytocin alone, P <0.05) … of contraction (−24.9±4.4% versus −52.4±9.1% in oxytocin alone, n=4, P <0.04).”
“The effect of oxytocin on contractility was further inhibited by L-NAME at 10−4 mol/L (−8.1±1.8%, P <0.01).”
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