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Last Updated: 3 years ago

Possible Interaction: Oxytocin and N-Methyl-3,4-Methylenedioxyamphetamine

Research Papers that Mention the Interaction

MDMA enhances release of monoamines (serotonin, norepinephrine, dopamine), hormones ( oxytocin , cortisol), and other downstream signaling molecules (BDNF) to dynamically modulate emotional memory circuits.
Progress in Neuro-Psychopharmacology and Biological Psychiatry  •  2018  |  View Paper
Acute MDMA or ecstasy ’ can generate increased levels of oxytocin and cortisol, and these neurohormonal changes may be important for its mood-enhancing and energy-activation effects in humans.
The effects of chronic MDMA usage on oxytocin still need to be investigated.
Behavioural pharmacology  •  2016  |  View Paper
In humans, MDMA increases plasma oxytocin and produces feelings of social affiliation.
Neuroscience & Biobehavioral Reviews  •  2015  |  View Paper
Recent evidence suggests that popular party drugs such as MDMA and gamma‐hydroxybutyrate (GHB) may preferentially activate brain oxytocin systems to produce their characteristic prosocial and prosexual effects.
British journal of pharmacology  •  2008  |  View Paper
MDMA but not LSD or d-amphetamine increased plasma concentrations of oxytocin.
Neuropsychopharmacology  •  2019  |  View Paper
Studies have shown that MDMA and amphetamine increase emotional empathy without affecting cognitive empathy; MDMA simultaneously leads to elevated levels of oxytocin , unrelated to its behavioral effects.
Human psychopharmacology  •  2018  |  View Paper
MDMA significantly increased plasma oxytocin concentrations.
Methylenedioxymethamphetamine MDMA ) increases oxytocin , empathy, and prosociality.
Oxytocin plays a critical role in emotion processing and social behavior and has been shown to mediate the prosocial effects of MDMA in animals.
PloS one  •  2018  |  View Paper
Oxytocin concentrations increased after MDMA administration but were not associated with behavioral effects.
Journal of psychopharmacology  •  2017  |  View Paper
One drug, 3,4-methylenedioxymethamphetamine (MDMA, ecstasy), seems to produce its prosocial effects by increasing plasma oxytocin levels, and the oxytocin system has been implicated in responses to several other drugs of abuse.
Journal of clinical psychopharmacology  •  2015  |  View Paper
MDMA but not methylphenidate increased the plasma levels of oxytocin and prolactin.
Journal of psychopharmacology  •  2014  |  View Paper
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