Possible Interaction: Oxytocin and Misoprostol

“RESULTS Increasing reservoir doses of mi oprostol up to 100 microg produced more rapid increases in modified Bishop scores, less need for oxy tocin, a nd a shorter time to vaginal delivery.”

“CONCLUSION: A single dose of misoprostol administered in the outpatient setting significantly decreases oxytocin use, largely due to labor within the ripening period.”

“Despite the numerous trials examining misoprostol for induction, the efficacy of a single outpatient dose of misoprostol followed by oxytocin induction is unknown.”

“RESULTS: A single dose of misoprostol significantly decreased the cumulative dose of oxytocin , the cumulative time of oxytocin administration, and the dose intensity of oxytocin (dose divided by time).”

“More women (10/18) who received oral misoprostol required oxytocin augmentation to complete the induction of labour compared with 4/20 women in the vaginal group (p < 0.05; Odds Ratio 2.8; 95% Cl 1.36 - 4.24).”

“Time induction-to-delivery at 12, 24 and 48 h and the need for oxytocin were reduced with misoprostol (P < 0.05).”

“CONCLUSION Oral misoprostol (100 μg) given in a maximum of two doses 4 hours apart significantly reduced the use of oxytocin in the management of women with ruptured membranes without labor at term.”

“ Misoprostol reduced the use of oxytocin stimulation of labor from 90% to 37% (P < .001) and was associated with approximately a 7-hour shorter elapsed time in the labor unit.”

“Conclusion: Misoprostol 50 μg was associated with less use of oxytocin in labor, a shorter induction to delivery interval and fewer cesarean sections for failure to progress when compared with extra‐amniotic PGF2α gel.”

“In the misoprostol group there was a significantly reduced need for augmentation of labor with oxytocin (OR=0.36; 95% C.I. 0.17–0.73) and delivery by cesarean section for failure to progress (OR=0.11; 95% C.I. 0.00–0.88).”

“Compared to prostaglandin F2 … for augmentation with oxytocin in labour was significantly reduced in women induced with prostaglandin … 0.46; 95%CI 0.23 to 0.93), vaginal misoprostol (OR 0.34; 95%CI 0.18 to 0.63) … (OR 0.42; 95%CI 0.22 to 0.78).”

“Mean time from induction to delivery and the need for oxytocin were significantly less in the misoprostol group.”

“Results : Compared with those women receiving oxytocin , patients given misoprostol had a significantly shortened labor (10.7 - 6.0 vs. 15.4 - 10.4 h, p h 0.001).”

“The mean time to delivery and the need for oxytocin was significantly less for subjects receiving misoprostol.”