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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Oxytocin
supplement:
Masoprocol
Research Papers that Mention the Interaction
“Intrauterine administration of nordihydroguaiaretic acid (NDGA) will maintain luteal function in sheep and also suppress the release of both oxytocin and prostaglandin F2 alpha (PGF2 alpha) suggesting that 5-lipoxygenase products of arachidonic acid may be involved in ovine luteolysis.”
Potential role for lipoxygenase products of arachidonic acid in prostaglandin F2 alpha-stimulated oxytocin release from the ovine corpus luteum.“Inhibition of the lipoxygenase metabolic pathway by nordihydroguaiaretic acid abolished AA-induced release of both OT and P4.”
“Mepacrine, NDHG and indomethacin also inhibited tonic contractions by OT in calcium-free EDTA treated medium.”
“Mepacrine, NDHGA and indomethacin, but not imidazol, inhibited in a dose-dependent way contractions induced by OT in the uterus.”
“ Nordihydroguaiaretic acid , which inhibits 5-lipoxygenase, however, totally abolished arachidonic acid- and reduced PLA2-stimulated oxytocin secretion.”
“3 Nordihydroguaiaretic acid , a lipoxygenase inhibitor, totally abolished the uterine response to either oxytocin or angiotensin II.”
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