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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“These data show inhibition by elevated circulating OT levels of glucocorticoid-induced, but not basal, leptin secretion in normal weight subjects, suggesting a possible role for OT in the regulatory control of leptin.”
Effect of systemic oxytocin administration on dexamethasone-induced leptin secretion in normal and obese men.“This review assesses the potential … and peripheral targets by which oxytocin may inhibit body weight gain, its regulation by anorexigenic and orexigenic signals, and its potential use as a therapy that can circumvent leptin resistance and reverse the behavioral and metabolic abnormalities associated with DIO and genetically obese models.”
“However, factors involved in the pathophysiology of osteoporosis, such as estrogens and leptin , are known to regulate oxytocin secretion.”
“Results: It was found that leptin stimulated the secretion of OT , IGFBP-3, and PGF.”
“These findings extend recent evidence suggesting that oxytocin circumvents leptin resistance and induces weight-loss in DIO animals through a mechanism involving activation of neurons in the NTS and AP, key hindbrain areas for processing satiety-related inputs.”
“Central administration of leptin significantly reduced both plasma oxytocin and hypothalamic noradrenaline responses to CCK at 20 min following the treatments.”
“In conclusion, leptin may inhibit oxytocin secretion by lowering noradrenergic neurotransmission in the PVN.”
“The main hypothesis was that leptin has an inhibitory action on oxytocin secretion and hypothalamic release of noradrenaline.”
“Using immunocytochemistry, we found that an anorectic dose of leptin administered into the third ventricle (3V) increased twofold the number of pPVN oxytocin neurons that expressed Fos.”
“The results suggest that leptin may inhibit the secretion of both oxytocin and vasopressin by inhibiting the electrical activity of neurones in the SON via direct action.”
“ Oxytocin inhibited the increase in leptin release due to dexamethasone without affecting leptin mRNA levels.”
Hormonal regulation of 18S RNA, leptin mRNA, and leptin release in adipocytes from hypothyroid rats.“Both PGE2 and leptin secretion were significantly increased by oxytocin treatment whilst adiponectin secretion was not.”
Oxytocin stimulates lipolysis, prostaglandin E2 synthesis, and leptin secretion in 3T3-L1 adipocytes
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