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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Oxytocin
drug:
Hexamethonium
Research Papers that Mention the Interaction
“The effects of OT were also blocked by hexamethonium , a ganglionic blocking agent, by atropine, a muscarinic receptor antagonist, and by N(omega)-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthesis.”
Possible neural mediation of the central effects of oxytocin on uterine motility.“ Hexamethonium (10 micromol x L(-1)) partly blocked the inhibition of oxytocin (1 U x L(-1)) on the contractile frenquency of CM.”
“Preliminary injection of a specific OT-receptor antagonist, hexamethonium , or bilateral pelvic nerve section impaired the effects of OT injected it.”
“Cardiac responses were induced when oxytocin was reinjected into active intrathoracic ganglionic sites after whole body administration of hexamethonium (10 mg/kg IV), but not after local administration of timolol into the ganglia.”
“Administration of hexamethonium systematically, to block nicotinic transmission in autonomic ganglia, prevented the cardioacceleration in response to intrathecal administration of oxytocin.”
“The ganglion-blocking agent hexamethonium (5 mg/kg iv) prevents the increase in uterine sensitivity to oxytocin during hypogastric nerve stimulation.”
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