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Last Updated: 3 months ago

Possible Interaction: Oxytocin and Hexamethonium

supplement:

Oxytocin

Research Papers that Mention the Interaction

The effects of OT were also blocked by hexamethonium , a ganglionic blocking agent, by atropine, a muscarinic receptor antagonist, and by N(omega)-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthesis.
American journal of physiology. Regulatory, integrative and comparative physiology  •  2005  |  View Paper
Hexamethonium (10 micromol x L(-1)) partly blocked the inhibition of oxytocin (1 U x L(-1)) on the contractile frenquency of CM.
World journal of gastroenterology  •  2003  |  View Paper
Preliminary injection of a specific OT-receptor antagonist, hexamethonium , or bilateral pelvic nerve section impaired the effects of OT injected it.
American journal of physiology. Regulatory, integrative and comparative physiology  •  2001  |  View Paper
Cardiac responses were induced when oxytocin was reinjected into active intrathoracic ganglionic sites after whole body administration of hexamethonium (10 mg/kg IV), but not after local administration of timolol into the ganglia.
Peptides  •  1990  |  View Paper
Administration of hexamethonium systematically, to block nicotinic transmission in autonomic ganglia, prevented the cardioacceleration in response to intrathecal administration of oxytocin.
Journal of the autonomic nervous system  •  1987  |  View Paper
The ganglion-blocking agent hexamethonium (5 mg/kg iv) prevents the increase in uterine sensitivity to oxytocin during hypogastric nerve stimulation.
British journal of pharmacology  •  1970  |  View Paper