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Last Updated: 2 years ago

Possible Interaction: Oxytocin and Enkephalin, Ala(2)-Mephe(4)-Gly(5)-

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supplement:

Oxytocin

drug:

Enkephalin, Ala(2)-Mephe(4)-Gly(5)-

Research Papers that Mention the Interaction

“In both the CellKey™ assay and the intracellular cAMP assay, OT alone exerted no direct agonistic effect on human MOR, but treatment with 10-6 M OT markedly enhanced the MOR signaling induced by 10-6 M endomorphin-1, β-endorphin, morphine, fentanyl, and DAMGO.”

Neuropeptide oxytocin enhances μ opioid receptor signaling as a positive allosteric modulator.

Journal of pharmacological sciences • 2018 | View Paper

“ Oxytocin release from neurophypophysial terminals is particularly sensitive to inhibition by the micro-opioid receptor agonist, DAMGO.”

Micro-opioid receptor preferentially inhibits oxytocin release from neurohypophysial terminals by blocking R-type Ca2+ channels.

Journal of neuroendocrinology • 2005 | View Paper

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