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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Oxytocin
drug:
Dihydrotestosterone
Research Papers that Mention the Interaction
“Testosterone and DHT significantly increased oxytocin concentrations secreted into the media from 0.86 +/- 0.11 ng/g of tissue (control) to 1.51 +/- 0.14 ng/g (p < 0.01) and 1.54 +/- 0.13 ng/g (p < 0.05), respectively.”
Effects of steroids on oxytocin secretion by the human prostate in vitro.“In the testis, oxytocin has been shown not only to modulate testosterone production but also to increase the activity of the enzyme 5 alpha-reductase which converts testosterone to dihydrotestosterone ( DHT).”
“Activity of both isoforms of 5alpha-reductase was significantly increased by OT , resulting in increased concentration of prostatic dihydrotestosterone.”
Regulation of 5alpha-reductase isoforms by oxytocin in the rat ventral prostate.“Simultaneous superfusion with either DHT or 3alpha-diol significantly blocked E-BSA-stimulated release of oxytocin.”
“The data suggest that both testosterone and DHT are capable of decreasing prostatic oxytocin concentrations.”
“In vitro treatment of goat testes … 6 h with 100 nM OT led to a 3.5-fold increase (… < 0.001) in 5 alpha-dihydrotestosterone ( DHT ) production in spite of the induced decrease in testosterone, suggesting that OT … only affects testosterone production but also modulates its conversion to DHT.”
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