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Last Updated: 7 months ago

Possible Interaction: Oxytocin and Carbetocin

supplement:

Oxytocin

Research Papers that Mention the Interaction

However, despite the potential benefits illustrated in this meta-analysis, the disparity between the cost of carbetocin and oxytocin suggests that locoregional cost-effectiveness analysis should be performed before any decision is made to adopt it for routine prophylaxis.
Taiwanese journal of obstetrics & gynecology  •  2018  |  View Paper
Oxytocin pretreatment results in attenuation of contractions induced by both oxytocin and carbetocin.
Anesthesiology  •  2016  |  View Paper
Carbetocin was most effective compared with the oxytocin 5 IU bolus subgroup with less need for additional uterotonic …. 9.3 %, p = 0.0067) and blood transfusions (2.2 vs. 3.6 %, p = 0.0357).ConclusionsCompared with oxytocin , prophylaxis … carbetocin after an elective CS diminished … uterotonics by more than 50 %.
Archives of Gynecology and Obstetrics  •  2012  |  View Paper
The increase of the activity induced by OXY and CBT indicating anxiolytic-like action was blocked by OXY antagonists.
Neuro endocrinology letters  •  2009  |  View Paper
All three compounds displayed antagonistic properties against oxytocin in vitro, with carbetocin being the strongest inhibitor (pA2 = 8.21) and carbetocin metabolite II (pA2 = 8.01) being stronger than carbetocin metabolite I (pA2 = 7.81).
However, maximal contractile effect of carbetocin was approximately 50% lower than that of oxytocin (2.70 +/- 0.12 g compared to 5.22 +/- 0.26 g) and EC50 was approximately ten times higher (48.0 +/- 8.20 nM compared to 5.62 +/- 1.22 nM).
European journal of pharmacology  •  1998  |  View Paper
Consequently, we determined the cost-effectiveness and budgetary impact of carbetocin against oxytocin in the Philippines.
On budget impact, the five-year total budget impact of a drug mix of carbetocin and oxytocin was 25.54 million USD (4.23 million USD for CS and 21.31 million USD for VD) compared with ‘ only oxytocin’ scenario.
BMC Health Services Research  •  2020  |  View Paper
The use of oxytocin reduced the farrowing duration by 18% and the birth interval by 17%, while carbetocin reduced the same responses by 27 and 23%, respectively (P < 0.01).
Theriogenology  •  2020  |  View Paper