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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Oxytocin
drug:
Carbetocin
Research Papers that Mention the Interaction
“Consequently, we determined the cost-effectiveness and budgetary impact of carbetocin against oxytocin in the Philippines.”
“On budget impact, the five-year total budget impact of a drug mix of carbetocin and oxytocin was 25.54 million USD (4.23 million USD for CS and 21.31 million USD for VD) compared with ‘ only oxytocin’ scenario.”
Economic evaluation of carbetocin as prophylaxis for postpartum hemorrhage in the Philippines“However, despite the potential benefits illustrated in this meta-analysis, the disparity between the cost of carbetocin and oxytocin suggests that locoregional cost-effectiveness analysis should be performed before any decision is made to adopt it for routine prophylaxis.”
“The longer half-life of carbetocin compared to oxytocin prevents additional doses or additional use of oxytocin.”
“The longer half-life of carbetocin compared to oxytocin prevents additional doses or additional use of oxytocin.”
“ Oxytocin pretreatment results in attenuation of contractions induced by both oxytocin and carbetocin.”
“Carbetocin was most effective compared with the oxytocin 5 IU bolus subgroup with less need for additional uterotonic …. 9.3 %, p = 0.0067) and blood transfusions (2.2 vs. 3.6 %, p = 0.0357).ConclusionsCompared with oxytocin , prophylaxis … carbetocin after an elective CS diminished … uterotonics by more than 50 %.”
“The use of oxytocin reduced the farrowing duration by 18% and the birth interval by 17%, while carbetocin reduced the same responses by 27 and 23%, respectively (P < 0.01).”
Effects of uterotonics on farrowing traits and piglet vitality: A systematic review and meta-analysis.“The increase of the activity induced by OXY and CBT indicating anxiolytic-like action was blocked by OXY antagonists.”
“All three compounds displayed antagonistic properties against oxytocin in vitro, with carbetocin being the strongest inhibitor (pA2 = 8.21) and carbetocin metabolite II (pA2 = 8.01) being stronger than carbetocin metabolite I (pA2 = 7.81).”
“However, maximal contractile effect of carbetocin was approximately 50% lower than that of oxytocin (2.70 +/- 0.12 g compared to 5.22 +/- 0.26 g) and EC50 was approximately ten times higher (48.0 +/- 8.20 nM compared to 5.62 +/- 1.22 nM).”
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