Possible Interaction: Oxytocin and Calcium Supplement

“In this project, we established that 0.1 &mgr;g/kg intravenous (IV) OT is the lowest anorexigenic dose, decreasing deprivation‐induced standard chow intake by ca.”

“ Oxytocin stimulates an increase in intracellular calcium in uterine myometrium by several mechanisms.”

“ Oxytocin increases myometrial intracellular free calcium by promotion of calcium entry and release of calcium from intracellular stores.”

“Incubation of U-87MG cells in the presence of oxytocin , resulted in a significant increase of intracellular calcium , specifically blocked by the OXTR antagonist L-371,257.”

“In the present study, we show that oxytocin induces an increase in the intracellular calcium in SH-SY5Y cells.”

“ Oxytocin and Bay K 8644 increased [Ca(2+)](i) in either calcium-containing or calcium-free media, and magnesium sulfate reduced this in both cases.”

“After 120 min of incubation with oxytocin and progesterone the total intracellular concentration of calcium was significantly higher (P < 0.0001 and P < 0.002, respectively) compared to buffer.”

“CONCLUSIONS (i) Ox tocin in creases total intracellular cal cium co ncentration concomitant with an increase in uterine contractile activity. (”

“ Oxytocin increases phosphoinositide turnover and intracellular calcium by a distinctly different pathway.”

“ Oxytocin caused an influx of calcium in cells depolarized by K+.”

“Removal of extracellular calcium ([Ca2+]o) reduced the oxytocin‐induced rise and abolished the PGE2‐induced rise in [Ca2+]i, thereby demonstrating that oxytocin but not PGE2 can mobilize intracellular stores of calcium.”

“Although tachyphylaxed cells produced … PGE2 with oxytocin, oxytocin increased intracellular calcium to levels higher than those seen in control cells (435 +/- 102 vs. 286 +/- 1.2) Actinomycin-D (P less than 0.001) and cycloheximide (P less than 0.05) inhibited PGE2 production caused by oxytocin, PMA, and EGF.”