Possible Interaction: Oxytocin and Atosiban

“CONCLUSION A 2-hour infusion of the ox tocin an tagonist ato siban re sulted in a significantly greater decline in contraction frequency compared with controls.”

“ OXT can amend the deficit but this effect was blocked by ASB.”

“Positive effects of oxytocin on insulin secretion were almost fully annulled by the oxytocin receptor antagonist, atosiban.”

“We have demonstrated that atosiban and nolasiban not only inhibit contractions elicited by OT , but also inhibit contractions and inflammation induced by PGF2α.”

“Critically, intranasal oxytocin administration restores the temporal compression effect in socially less proficient individuals, whereas the administration of atosiban , a competitive antagonist of oxytocin , diminishes the effect in socially proficient individuals.”

“In the control group Atosiban re-established NO levels that were reduced after incubation with oxytocin , while in preterm samples NO levels were not only re-established but, after incubation with Atosiban, significantly increased compared to basal levels.”

“Co-treatment with oxytocin and oxytocin receptor antagonist— atosiban —resulted in significant increase of MAP2 gene expression in SK-N-SH cells.”

“Surprisingly, oxytocin with atosiban significantly increased mRNA levels for both BDNF and NGF.”

“ Atosiban , a newer drug, is a competitive antagonist of oxytocin and has been claimed to have fewer cardiovascular side effects.”

“ Atosiban , a newer tocolytic drug, is a competitive antagonist of oxytocin and has fewer cardiovascular side effects.”

“ Atosiban acts through selective, competitive inhibition of both oxytocin and vasopressin, so that there are reasons to assume that a tocolytic effect can also be achieved earlier in the pregnancy.”