Possible Interaction: Oxytetracycline and Calcium Supplement

“This mainly concerns the reduction of the interaction between calcium ions and OTC.”

“Antibiotics tested for potential block of Ca++ uptake included the aminoglycosides neomycin and streptomycin, the lincosamide clindamycin, oxytetracycline and polymyxin B. Drugs were applied in concentrations ranging from 1 to 1000 microM. Uptake of 45Ca was determined during depolarization induced by an elevated K+ concentration (77.5 mM).”

“Reducing dietary calcium from 0.8 to 0.4% significantly increased serum levels of CTC and OTC.”

“Reduction of the dietary calcium level from 1.18 to 0.18% resulted in more than a two-fold increase in serum levels of oxytetracycline (OTC) or chlortetracycline (CTC).”

“The complex formed via Ca 2 + coordinating to the hydroxyl group of OTC contributes to the fluorescence enhancement, which has been proved by several characterization methods including UV-vis analysis, binding constant determination, and fluorescence titration.”

“Upon the addition of Ca 2 + , the fluorescence of OTC could be significantly enhanced with rapid response and high sensitivity, and achieved a good limit of detection as low as 125 nM in aqueous solution.”

“Despite a two-… increase in OTC adsorbed in … presence of Ca or Mg, both solid-state nuclear magnetic resonance and infrared signatures of the OTC functional groups involved in metal complexation implied that the formation of an inner-sphere ternary complexation was not significant in stabilizing the adsorbate structures.”

“The analysis of X-ray photoelectron spectroscopy (XPS) showed that binding energy and atomic percentage of Al, Fe, C, O, N, Si, Mg and Ca altered after the amended with OTC or Pb.”

“The Ca2+ and Mg2+ in the natural water sample accounted for enhancement (pH 7.3) and inhibition (pH 9.0) of photodegradation of TC and OTC due to the formation of metal-ions complexes.”

“Although TC and OTC in large amounts can alter the normal metabolic interrelationships between calcium ions and bone tissue, they have no significant value as agents for reducing a potentially hazardous body or skeletal burden of radiostrontium.”

“ Oxytetracycline (OTC) was shown to have a greater chemical affinity for calcium ions than for strontium ions in vitro.”