Possible Interaction: Oxaliplatin and Resveratrol

“The xenograft experiments showed that exposure to Res or Oxa suppressed tumor growth; and the efficacy was evidently augmented by the co-treatment of Res and Oxa.”

“Greatest synergism was observed when resveratrol was administered first followed by the platinum drug (cisplatin or oxaliplatin ) 2 h later, and the least synergism was achieved when the two types of compounds were administered as a bolus.”

“Conclusion Resveratrol has an antichemosensitizing effect upon cotreatment with oxaliplatin in HCT colon cancer cells.”

“In order to maximize oxaliplatin therapy, we examined whether resveratrol , a natural phytochemical known to have chemopreventive effects on cancers, can have a chemosensitizing effect upon cotreatment with oxaliplatin.”