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“Association of 125I-t-PA with liver endothelial cells was Ca(2+)-dependent and mannose-specific, since ovalbumin (a mannose-terminated glycoprotein) inhibited the cell association of t-PA.”
“The association of t-PA with endothelial cells could be inhibited 80% by the mannose-terminated glycoprotein ovalbumin , suggesting that the mannose receptor plays a major role in the recognition of t-PA by endothelial liver cells.”