Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 6 months ago

Possible Interaction: Ovalbumin and Pyrilamine



Research Papers that Mention the Interaction

A combination of all three compounds mepyramine , methysergide and montelukast) reduced ovalbumin‐induced microvascular leakage in airway tissue to basal levels (70 – 78%) and almost completely inhibited bronchospasm (92%).
British journal of pharmacology  •  2001  |  View Paper
Higher doses of either methiotepine (2.0 mg kg−1) or mepyramine (20 mg kg−1) did decrease ovalbumin‐induced eosinophil infiltration (by 67%, P<0.05 and 73%, respectively), whereas no effects of these antagonists were observed on ovalbumin‐specific IgE levels in serum.
British journal of pharmacology  •  1998  |  View Paper
Moreover, the histamine H1 receptor antagonist pyrilamine (0.3 microM) reversed the potentiation elicited by ovalbumin.
The Journal of pharmacology and experimental therapeutics  •  1992  |  View Paper
The H1-antagonist, mepyramine (10 mg/kg intraperitoneally), almost completely blocked the effect of OA , suggesting that OA-induced bronchoconstrictor responses are histamine (H1 receptor) mediated.
The Journal of allergy and clinical immunology  •  1990  |  View Paper
In the presence of 10(-6)M atropine, pyrilamine , and indomethacin, concentrations of ovalbumin from 10(-9) to 10(-8) g per ml produced marked contraction of the bronchi.
The American review of respiratory disease  •  1976  |  View Paper