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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ovalbumin
drug:
Pyrilamine
Research Papers that Mention the Interaction
“A combination of all three compounds mepyramine , methysergide and montelukast) reduced ovalbumin‐induced microvascular leakage in airway tissue to basal levels (70 – 78%) and almost completely inhibited bronchospasm (92%).”
Mediator involvement in antigen‐induced bronchospasm and microvascular leakage in the airways of ovalbumin sensitized Brown Norway rats“Higher doses of either methiotepine (2.0 mg kg−1) or mepyramine (20 mg kg−1) did decrease ovalbumin‐induced eosinophil infiltration (by 67%, P<0.05 and 73%, respectively), whereas no effects of these antagonists were observed on ovalbumin‐specific IgE levels in serum.”
“Moreover, the histamine H1 receptor antagonist pyrilamine (0.3 microM) reversed the potentiation elicited by ovalbumin.”
“The H1-antagonist, mepyramine (10 mg/kg intraperitoneally), almost completely blocked the effect of OA , suggesting that OA-induced bronchoconstrictor responses are histamine (H1 receptor) mediated.”
“In the presence of 10(-6)M atropine, pyrilamine , and indomethacin, concentrations of ovalbumin from 10(-9) to 10(-8) g per ml produced marked contraction of the bronchi.”
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