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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Orotic Acid
drug:
Uridine
Research Papers that Mention the Interaction
“Exposure to OA results in an accumulation of uridine nucleotides and a decrease in adenosine nucleotides.”
Effect of orotic acid on in vivo DNA synthesis in hepatocytes of normal rat liver and in hepatic foci/nodules.“Exposure to orotic acid results in an imbalance in nucleotide pools characterized by an increase in uridine nucleotides and a decrease in adenosine nucleotides.”
“After application of orotic acid and uridine a transport of radioactive material, presumably RNA, could be observed in the processes of the injected neurons at a distance of about 200-500 mum.”
“Von Euler et al. (11) have shown that the amount of uridine coenzymes in the liver of rats is increased by giving orotic acid , a precursor in the biosynthesis of the uridine moiety.”
“With identical 20-min pulse-labeling incorporation periods, the incorporation efficiency into RNA for orotic acid was 15-fold that of uridine and 5-fold that of guanine.”
“Marked alterations in the concentration of various acid-soluble nucleotides of liver also result from the ingestion of erotic acid , with a 400 70 elevation of uridine nucleotides and a 50 70 depression in adenine nucleotides being the most prominent (4).”
AN OROTIC ACID-INDUCED, ADENINE-REVEREED INHIBITION OF HEPATIC LIPOPROTEIN SECRETION IN THE RAT.
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