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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Orotic Acid and Phenobarbital

supplement:

Orotic Acid

Research Papers that Mention the Interaction

The fatty liver induced by orotic acid and a high sucrose diet in male rats was prevented by the administration of DHEA and/or phenobarbital ( PB).
The Journal of veterinary medical science  •  1998  |  View Paper
However, our earlier studies indicated that PB inhibited DNA synthesis in vitro in hepatocytes isolated from both surrounding non-nodular liver and hepatic nodules promoted by orotic acid (OA).
Carcinogenesis  •  1994  |  View Paper
Interestingly, PB inhibited DNA synthesis not only in hepatocytes from non-nodular surrounding liver but also in hepatocytes from persistent hepatic nodules initiated with 1,2-dimethylhydrazine and promoted with OA.
Carcinogenesis  •  1992  |  View Paper