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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Orotic Acid
drug:
Oxonic Acid
Research Papers that Mention the Interaction
“In the presence of 5-azaorotic acid , the total anabolic conversion of orotic acid is strongly decreased both in liver and in bacterial extracts.”
Metabolic transformations of 5-azauracil and 5-azaorotic acid in mouse liver and Escherichia coli. Effect on the synthesis of pyrimidines.“Effective blockade of the utilization of exogenous orotic acid by 5‐azaorotic acid was sustained in patients for 6 hours after intravenous administration of the compound.”
“Intraperitoneal injection of 5-azaorotate (0.3 µmole/gm) into mice caused an 80 per cent inhibition of the utilization of orotic acid but did not affect the incorporation of uridine into the liver.”
“The pyrimidine analogs, 5-azaorotic acid (6 × 10-7 m) and 5-azauracil (2 × 10-4 m), caused approximately 50 per cent inhibition of the metabolism of orotic acid by cell-free extracts from mouse liver or L5178Y leukemia cells.”
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