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“Administration of pyridoxine stimulates residual OAT activity and is associated with a significant reduction in ornithine plasma levels in some genetically determined responsive patients.”
American journal of ophthalmology • 1980 | View Paper
“In vivo response to vitamin B6 is documented in three of the four patients by significant reduction of fasting serum ornithine and increase of lysine after oral B6 supplementation.”
American journal of human genetics • 1980 | View Paper
“ Ornithine withdrawal from the perifusion medium resulted in a decay of enzyme activity observed after 90 min; this decay was prevented by addition of 55 microM pyridoxal to the medium.”
“The pyridoxamine form of the enzyme, produced by the reaction of the pyridoxal enzyme with ornithine , reverts to the pyridoxal form in the absence of the second substrate.”