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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“We also reported that arginine, citrulline or ammonia plus ornithine , all of which increase arginine, inhibit GSA synthesis even in the presence of urea.”
Inhibition of arginine synthesis by urea: A mechanism for arginine deficiency in renal failure which leads to increased hydroxyl radical generation“The plasma concentration of urea and the liver concentration of N-acetylglutamate in rats given ornithine were each significantly higher than in the control rats.”
“By increasing ornithine carbamoyltransferase activity, ornithine enhances the conversion of ammonia to citrulline and urea.”
“In rats injected with four doses of NH4Cl (2.5 mmol/kg), arginine or ornithine pretreatment increased the urea excretion and normalized the orotic acid excretion.”
“Injections of urea cycle intermediates (ammonia, ornithine , aspartic acid and arginine) all accelerated urea production, while no response was detected for glutamine and glutamic acid.”
“The rate of urea production continued to increase as ornithine was varied from 0 to 40 mM. 6.”
“Our data also explain the early report that ornithine transaminase production is induced when cells are grown with urea.”
Synergistic Operation of the CAR2(Ornithine Transaminase) Promoter Elements in Saccharomyces cerevisiae
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