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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ornithine
drug:
Clavulanic Acid
Research Papers that Mention the Interaction
“Furthermore, some amino acids such as arginine and ornithine , could serve as potential precursors to increase clavulanic acid yield.”
Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review“Compared to the … deletion mutant, ornithine increased CA production by 3.24- and 6.51-fold in the pHN11 and pHN12 transformants, respectively, glycerol increased CA by 2.96- and 6.21-fold, respectively, and ornithine and glycerol together increased CA by 3.72- and 7.02-fold, respectively.”
“ Ornithine and arginine (5 to 20 mM), but not glutamic acid or proline, exerted a concentration-dependent stimulatory effect on the biosynthesis of clavulanic acid in both resting-cell cultures and long-term fermentations of Streptomyces clavuligerus.”
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