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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Orlistat and Fat Soluble Vitamin Product

Research Papers that Mention the Interaction

Abstract: Orlistat , a lipase inhibitor taken with meals at doses of 60 mg (available over-the-counter) or 120 mg (prescription only) for treatment of obesity, is known to impair the absorption of fat-soluble molecules.
Journal of cardiovascular pharmacology  •  2012  |  View Paper
The selection of drugs for interaction studies with orlistat was based … testing related to orlistat-induced inhibition of fat absorption (ie, orlistat may … as fat-soluble vitamins ), (2) drugs with a narrow therapeutic index, and (3) concomitant medications … population, such as glucose-lowering agents, hypolipidemic, antidiabetic, and antihypertensive drugs.
Journal of clinical pharmacology  •  2012  |  View Paper
Orlistat reduces dietary fat … effects on fat soluble vitamins especially the antioxidant vitamins A and E. The aim of this study was to determine and compare the effects of … orlistat therapy and a combination of orlistat with aerobic exercise training on lipid peroxidation and antioxidative defense in obese subjects.
The Tohoku journal of experimental medicine  •  2005  |  View Paper
Due to its ability to block fat absorption, orlistat also has the capability to inhibit absorption of fat-soluble vitamins.
The Annals of pharmacotherapy  •  2001  |  View Paper
Orlistat causes a 30–60% reduction in absorption of the fat-soluble vitamins beta-carotene and vitamin E acetate and 2–12% of subjects treated with orlistat develop abnormally low levels of vitamins A, D, E, or beta-carotene.
AIDS research and human retroviruses  •  2012  |  View Paper
Orlistat interferes with the absorption of many drugs (such as warfarin, amiodarone, ciclosporin and thyroxine as well as fat-soluble vitamins ), affecting their bioavailability and effectiveness.
Drug safety  •  2008  |  View Paper
Orlistat use may be associated with patient alteration of diet to compensate for adverse effects or other … warfarin control, including direct effect on absorption of vitamin K. CONCLUSIONS: The introduction of chronic dosing of orlistat … fat-soluble vitamins , including vitamin K, with the result … of warfarin may be required.
The Annals of pharmacotherapy  •  2003  |  View Paper
Orlistat interferes with the absorption of fat soluble vitamins , but no data are available about interfering with cyclosporine (CyA) absorption in the manufacturer’s brochure.
Transplantation proceedings  •  2002  |  View Paper
The incidence of gastrointestinal adverse events was consistently higher in orlistat groups compared with placebo, and orlistat use was associated with lower serum levels of fat-soluble vitamins.
Health technology assessment  •  2001  |  View Paper
Because orlistat may decrease the absorption of fat‐soluble vitamins , a standard multiple‐vitamin supplement is recommended daily during therapy to prevent abnormalities in vitamin serum concentrations.
Pharmacotherapy  •  2000  |  View Paper
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