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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Omeprazole
supplement:
Vitamin B 12
Research Papers that Mention the Interaction
“In the gastric aspirates obtained after omeprazole there was a slight inhibition in cobalamin release after 5 and 30 min (p less than 0.05).”
Effect of gastric anacidity on the release of cobalamins from food and their subsequent binding to R-protein.“Protein-bound cyanocobalamin absorption decreased (P < 0.05) to 0.9% 0.3% (P = 0.031) and 0.4% 0.1% (P = 0.031) after 2 weeks of 20-mg and 40-mg omeprazole groups , respectively.”
“The studies reviewed in this article clearly show that omeprazole therapy will decrease the absorption of vitamin B12 by preventing its cleavage from dietary proteins.”
“ Vitamin B12 levels, but not serum folate levels or any hematological parameter, were significantly (P = 0.03) lower in patients treated with omeprazole , especially those with omeprazole-induced sustained hyposecretion (P = 0.0014) or complete achlorhydria (P < 0.0001).”
“Based upon present experience, serum cobalamin concentration should be monitored in patients undergoing omeprazole therapy for several years.”
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