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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Omeprazole
supplement:
Thiamine
Research Papers that Mention the Interaction
“ Omeprazole inhibited two thiamin diphosphate-dependent enzymes, pyruvate decarboxylase (EC 4.1.1.1, PDC) from Zymomonas mobilis and transketolase (EC 2.2.1.1, TK) from human erythrocytes.”
Inhibition of transketolase and pyruvate decarboxylase by omeprazole.“Conversely, the guanidine/H+ antiport was inhibited by unlabeled thiamine and thiamine analogues; omeprazole caused an approximately fourfold increase in thiamine transport rate.”
A Thiamine/H+ Antiport Mechanism for Thiamine Entry into Brush Border Membrane Vesicles from Rat Small Intestine
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