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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Omecamtiv Mecarbil
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“Experiments with permeabilized human myocardium demonstrate that OM increases calcium sensitivity and slows force development (ktr) in a concentration-dependent manner, whereas the maximally activated force is unchanged.”
Omecamtiv Mecarbil Enhances the Duty Ratio of Human β-Cardiac Myosin Resulting in Increased Calcium Sensitivity and Slowed Force Development in Cardiac Muscle*“ OM increased the calcium sensitivity of type I single muscle fibers.”
Omecamtiv mecarbil lowers the contractile deficit in a mouse model of nebulin-based nemaline myopathy“Biophysical and biochemical studies have found that OM increases calcium (Ca2+) sensitivity of contraction by prolonging the myosin working stroke and increasing the actin-myosin cross-bridge duty ratio.”
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