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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Olmesartan
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“However, at high concentrations (150~300 µM), olmesartan rather enhanced the ACh-evoked CA secretion.”
“ Olmesartan (5~50 µM) perfused into an adrenal vein for 90 min produced dose- and time-dependent inhibition of the CA secretory responses evoked by ACh (5.32 mM), high K(+) (56 mM, a direct membrane-depolarizer), DMPP (100 µM) and McN-A-343 (100 µM).”
“Taken together, these results show that olmesartan at low concentrations inhibits the CA secretion evoked by cholinergic stimulation (both nicotininc and muscarinic receptors) as well as by direct membrane depolarization from the rat adrenal medulla, but at high concentrations it rather potentiates the ACh-evoked CA secretion.”
Inhibitory effects of olmesartan on catecholamine secretion from the perfused rat adrenal medulla.
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