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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Oligosaccharides
supplement:
Polypeptides
Research Papers that Mention the Interaction
“B) The galactosylation profiles obtained for the IgG heavy chains, in particular the preference for galactosylation of … rather than the Man (alpha 1-->3) arm, contrary to the beta-galactosyltransferase specificity, suggest that the polypeptide chain may act as a template to … and hence the proportions of each oligosaccharide ….”
Control of IgG/Fc glycosylation: a comparison of oligosaccharides from chimeric human/mouse and mouse subclass immunoglobulin Gs.“It appears that there is a subtle interplay between the polypeptide and oligosaccharide structures to generate these ligand binding sites.”
“The attachment of an oligosaccharide unit to the polypeptide at the site of occupancy can enhance solubility, improve folding, facilitate secretion, modulate antigenicity, and increase in vivo half-life of the glycoprotein.”
Controlling N-linked glycan site occupancy.“Direct interactions are observed between hinge polypeptides , the glycosylated loop of one CH2 domain, and the oligosaccharide.”
Crystallographic structure of an intact IgG1 monoclonal antibody.
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