“Taken together, these findings identify AOS as a potent compound that prevents acute DOX cardiotoxicity, at least in part, by suppression of oxidative stress and endoplasmic reticulum-mediated apoptosis.”
“We found that AOS pretreatment markedly increased the survival rate of mice insulted with DOX , improved DOX-induced cardiac dysfunction and attenuated DOX-induced myocardial apoptosis.”