Possible Interaction: Oleic Acid and Vitamin E

“A transient activation of CYP4F2 gene followed by a repression response was observed in HepG2 cells during the … lipogenic and cytotoxic agent palmitic acid; such gene repression effect was further exacerbated by the co-treatment with oleic acid … α-tocopherol and was also observed for … isoforms 1 and 2.”

“ Vitamin E counteracted the inhibitory effect of chlorinated oleic acid on HepG2 cells, but did not significantly affect the fatty acid effect on HMVEC or IHKE.”

“A consistent observation is that vitamin E supplements or oleic acid-rich diets increase OR.”

“Supplementation with micellized-d-α-tocopherol decreased the C18:0 proportion (P = 0.04) and the C18:1 n-9 to C18:0 ratio (P = 0.03) in milk, whereas the C18:1 n-7 proportion increased (P = 0.03) compared to dl-α-tocopheryl acetate.”

“ Vitamin E exerted a cholesterol- or cholesteryl ester-lowering effect on both 10% palmitic and 10% oleic acid diets.”

“Dietary ascorbic acid seemed not to affect fatty acid distribution significantly, but when vitamin E was added to the diet, the stearic acid percentage rose and oleic acid percentage was lower.”

“Bratzler, Loosli, Krukovsky & Maynard (1950) found that tocopherol supplementation of a diet low in tocopherol and fat markedly affected the composition of body fats by increasing the content of oleic acid.”

“The surface pressure--… mixed monolayers of alpha-tocopherol and …, oleic acid or linoleic acid deviated positively from those calculated on the basis of the additivity rule, and the magnitude depended … of the phytyl side chain in alpha-tocopherol and on the degree of unsaturation of the fatty acid chains.”

“The compounds which have in vivo vitamin E activity or their structural analogs strongly inhibited hemin, hemoglobin, and cytochrome c-catalyzed oleic acid oxidation.”