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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Oleic Acid
drug:
Thyroxine
Research Papers that Mention the Interaction
“At the relevant total and free drug concentrations, the inhibitory effect of oleic acid on drug binding and its influence on drug-induced displacement of T4 were concordant in the order: meclofenamic acid greater than aspirin greater than mefenamic acid greater than diflunisal greater than furosemide greater than fenclofenac.”
Interactions between oleic acid and drug competitors influence specific binding of thyroxine in serum.“The data suggest that the serum concentrations of albumin and other T4-binding proteins are important in modulating the DFT4-increasing effect of oleic acid and that oleic acid may contribute to the reduced serum binding of T4 in nonthyroidal illness.”
“Treatment of rats with thyroxine resulted in a 1.5-fold (P < 0.025) increase in the relative percent of oleic acid in cardiac phosphatidylethanolamine.”
Thyroxine stimulates the acylation of lysophosphatidylethanolamine in rat heart.“Basal TSH was less sensitive to inhibition by thyroxine (T4) in the presence of oleic acid/albumin at a ratio of 6 or greater, and inhibition by oleic acid was less than additive with T4 at a ratio of 6 or greater.”
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