“It was found that OA content markedly increased TEN absorption when compared to the control gel; the highest drug flux was obtained by 15% of OA.”
“Skin pretreatment with OA , independently of the vehicle used to dissolve the fatty acid, dramatically improved TEN percutaneous penetration.”
“The absorption rate of TEN increased in parallel with increasing OA concentration, due to the alteration of the stratum corneum caused by this enhancer.”