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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Oleic Acid
drug:
Tamoxifen
Research Papers that Mention the Interaction
“In contrast, although raloxifene with oleic acid did not increase the intracellular concentrations of triglyceride, tamoxifen treatment in the presence of oleic acid or very low density lipoprotein significantly increased (P<0.05) the triglyceride concentrations.”
In vitro study of the effect of raloxifene on lipid metabolism compared with tamoxifen.“In the presence of oleic acid and stearic acid (10 microM) the growth inhibitory effect of tamoxifen in A549 cells was greatly enhanced, unlike effects mediated by the anti-oestrogen binding protein described in other cells where these fatty acids had no effect.”
“Saturation analysis … of oleic acid progressively decreased the … these sites for [3H]tamoxifen without decreasing the total number of binding sites; however, the apparent dissociation constant did not vary linearly with … acid concentration, suggesting that the inhibition of [3H]tamoxifen binding by fatty acid was not competitive in nature.”
Interaction of unsaturated fatty acids with anti-oestrogen-binding sites.
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