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Possible Interaction: Oleic Acid and Tamoxifen


Oleic Acid

Research Papers that Mention the Interaction

In contrast, although raloxifene with oleic acid did not increase the intracellular concentrations of triglyceride, tamoxifen treatment in the presence of oleic acid or very low density lipoprotein significantly increased (P<0.05) the triglyceride concentrations.
European journal of endocrinology  •  2000  |  View Paper
In the presence of oleic acid and stearic acid (10 microM) the growth inhibitory effect of tamoxifen in A549 cells was greatly enhanced, unlike effects mediated by the anti-oestrogen binding protein described in other cells where these fatty acids had no effect.
Biochemical pharmacology  •  1994  |  View Paper
Saturation analysis … of oleic acid progressively decreased the … these sites for [3H]tamoxifen without decreasing the total number of binding sites; however, the apparent dissociation constant did not vary linearly with … acid concentration, suggesting that the inhibition of [3H]tamoxifen binding by fatty acid was not competitive in nature.
The Biochemical journal  •  1987  |  View Paper