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Last Updated: 3 years ago

Possible Interaction: Oleic Acid and Pulmonary Surfactants

Research Papers that Mention the Interaction

Oscillating bubble studies showed that OA prevented lavaged calf surfactant [0.5 mM phospholipid (PL)] from lowering surface tension below 15 mN/m at or above a molar ratio of OA/PL = 0.5.
The inhibitory effects of oleic acid (OA) on the surface activity of pulmonary surfactant were characterized by use of the oscillating bubble surfactometer, the Wilhelmy balance, and excised rat lungs.
Together these findings suggested that OA inhibited pulmonary surfactant activity by disrupting the rigid interfacial film responsible for the generation of very low surface tension during dynamic compression.
Wilhelmy balance studies showed that OA did interfere with the ability of spread films of surfactant to reach low surface tensions during dynamic compression.
Journal of applied physiology  •  1992  |  View Paper
It was found that the utilization of oleic acid as a surfactant during their synthesis greatly decreased their particle size from micron to submicron scale, while adding a small amount of ethanol further reduced their particle size.
Materials  •  2019  |  View Paper