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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Oleic Acid
drug:
Propylene Glycol
Research Papers that Mention the Interaction
“The drug transport was further increased with the incorporation of oleic acid as penetration enhancer, especially when used in combination with propylene glycol.”
Delivery of ethinylestradiol from film forming polymeric solutions across human epidermis in vitro and in vivo in pigs.“Further studies are needed with OA since PG solvent may have concealed the possible impact of OA.”
“The results also showed that PG and OA improved the diffusion of each other and created faster, yet reversible changes of the skin peaks.”
“We also concluded that PG and OA have potential synergistic reversible effect on the skin.”
“The enhancement factors with the addition of oleic acid or linoleic acid to PG were about 1250 and 450, respectively.”
“In contrast, topical applications of 0.3 M oleic acid in propylene glycol for 1 h increased transepidermal water loss significantly.”
Structural and functional effects of oleic acid and iontophoresis on hairless mouse stratum corneum.“Two fatty acids with the double bond at the delta9 position, palmitoleic acid (omega7, delta9) and oleic acid (omega9, delta9), enhanced PG flux into the dermis and increased the dermal steady state level of PG.”
“It is found that oleic acid in propylene glycol increases both the initial flux and the flux at steady state.”
“A combination of oleic acid with propylene glycol was synergistic with a ratio of 1:2 w/w being the best.”
Transdermal Delivery of Nisoldipine: Refinement of Vehicles.
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