Possible Interaction: Oleic Acid and Phospholipids

“Experiments with artificial membranes of different lipid composition did not answer this quess tion and only showed that the presence of OA in these complexes increases their affinity for phospholipid vesicles [6, 7].”

“The polyunsaturated fatty acid (PUFA) levels in cell phospholipids were reduced by exogenous oleic acid to half that of nonsupplemented cells at all PDL tested.”

“… phospholipid fatty acid … oleic acid 18:1(n-9) and docosahexaenoic acid 22:6(n-3) were significantly higher in the trained (10.9 +/- 0.5% and ….4% of total fatty acids, respectively) than the untrained leg (8.8 +/- 0.5% and 2.6 +/- 0.4%, P < 0.05).”

“The results suggest that long-term FA modification of endothelial cells differentially alters the sensitivity of their membrane phospholipids to peroxidation: long-term modification with oleic acid may protect against lipid peroxidation, whereas linoleic acid may increase sensitivity to peroxidation.”

“Alterations in unsaturated-to-saturated fatty acid ratios in human lymphocyte phospholipids resulted from incubation of the cells in medium supplemented with oleic acid (18:1) or γ-linolenic acid (18:3).”

“Major changes in unsaturated-to-saturated fatty acid ratios in phospholipids were accompanied by less than twofold enhancement or no change in natural killing (NK) after oleic acid supplement and by less than twofold depression after γ-linolenic acid supplement.”

“Distribution of radioactivity and specific activity of oleic acid in the triglycerides and phospholipids were significantly reduced by the analogue.”

“An analysis of the fatty acid composition of the erythrocyte membrane phospholipids showed significant correlations between the content of oleic acid , and arachidonic acid, and the ouabain-sensitive K+ influx (as well as the total K+ influx).”

“Oscillating bubble studies showed that OA prevented lavaged calf surfactant [0.5 mM phospholipid ( PL )] from lowering surface tension below 15 mN/m at or above a molar ratio of OA/PL = 0.5.”

“ Oleic acid reduced the synthesis of N-methylated phospholipids and stimulated the methyl group incorporation into nonpolar lipids in a concentration-dependent manner.”

“The unsaturated fatty acids palmitoleic, oleic , linoleic, linolenic, and arachidonic acids, some of which have been reported to be weak tumor promoters, stimulated protein kinase C activity in the presence of phospholipids , as well as causing some activation in the absence of phospholipids.”