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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Oleic Acid
drug:
Losartan
Research Papers that Mention the Interaction
“ Losartan , an angiotensin type 1 (AT1) receptor antagonist, blocked the synergistic interaction between Ang II and oleic acid , whereas the AT2 receptor antagonist PD 123319 did not.”
Oleic acid and angiotensin II induce a synergistic mitogenic response in vascular smooth muscle cells.“However, the OA induced kidney damage was decreased by losartan significantly in male (P < 0.05) and insignificantly in female rats.”
“In addition, co-treatment of OA and losartan decreased lung water content significantly in male rats (P < 0.05).”
“Results: Co-treatment of OA and losartan increased the serum levels of blood urea nitrogen significantly (P < 0.05) and creatinine insignificantly in both gender.”
Protective Role of Angiotensin II Type 1 Receptor Blocker on Short Time Effect of Oleic Acid Induced Lung and Kidney Injury
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