Possible Interaction: Oleic Acid and Linolenic Acid

“Linoleic (18:2n-6c) and alpha-linolenic (18:3n-3) acids increased at the expense of oleic acid (18:1n-9c) in the cholesteryl ester, TG, and phospholipid subfractions.”

“Importantly, we observed that these effects are additively regulated by OA and ALA in combination when compared to control in OE19 and OE33 esophageal cancer cell lines.”

“RESULTS Both OA an d ALA si gnificantly down-regulated cell proliferation, adhesion and/or migration.”

“The accumulation of alpha-linolenic acid was compensated by a decrease of oleic acid.”

“RESULTS … ic or … olenic acid in creased the brain weight (+36.7% and +45%, P < 0.01), the density of BrdU (bromodeoxyuridine)- (+80% and +115%; P < 0.01), and DAPI (…-2-phenylindole)-positive cells (+64% and +22%, P < 0.05) of PD2 TS mice with respect to the vehicle-treated TS mice.”

“Thus: 1) EFA deficiency has been shown to enhance desaturation of palmitic and stearic acid in lung; 2) in vitro addition of linoleic or linolenic acid inhibited desaturation significantly; and 3) oleic acid was inhibitory but to a lesser and more variable extent.”

“The proportions of alpha-linolenic acid correlated inversely with oleic and linoleic acids in the seed oil.”