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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Oleic Acid
drug:
Bosentan
Research Papers that Mention the Interaction
“ConclusionsPretreatment, but not treatment, with bosentan , in the dose used, blunted the oleic acid-induced increase in pulmonary vascular resistance, suggesting that endothelins contribute to the increase in pulmonary vascular tone in the early stages of oleic acid lung injury.”
Endothelin receptor blockade in canine oleic acid-induced lung injury“ Bosentan and Ro 46-8443 (at doses of 30 and 10 mg x kg(-1) respectively) inhibited the neutrophil infiltration induced by oleic acid by approx.”
“ Bosentan , the antagonist of endothelin receptors (ET(A) and ET(B)) or the selective ET(B) receptor antagonists Ro 46-8443 or … 1 h before oleic acid at doses of 30, 10 and 30 mg x kg(-1) respectively) reduced the effect of oleic acid by 71%, … 79% respectively.”
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