Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Ofloxacin and Ferrous Sulfate


Ferrous Sulfate

Research Papers that Mention the Interaction

Concomitant ingestion of ferrous sulphate reduced the AUC and peak plasma concentration of ofloxacin by 25% (P < 0.01) and 36% (P < 0.01), respectively.
It would also be advisable not to take ofloxacin with ferrous sulphate , especially if the organism causing infection is only moderately susceptible.
British journal of clinical pharmacology  •  1994  |  View Paper
In-vitro studies using simulated gastric fluid showed that ferrous sulphate , aluminium hydroxide and calcium carbonate reduced ofloxacin availability to 67.4%, 69.3% and 73.8%, respectively.
The Journal of antimicrobial chemotherapy  •  1991  |  View Paper